It’s the Duke Blue Devils vs Houston in the Final Four of the March Madness bracket. Here’s our prediction, pick for the 2025 NCAA Tournament game.

The Duke Blue Devils are now the favorite to bring home the national title at -110.Start the day smarter. Get all the news you need in your inbox each morning. The Florida Gators are the second choice to win the NCAA Tournament at +300 odds.

No. 1 seed Duke, led by National Player of the Year candidate Cooper Flagg, will square off against No. 1 seed Houston, while No. 1 seed Florida faces No. 1 Auburn in the national semifinals. Florida will make its first appearance in the Final Four since 2014.

Emmanuel Acho, LeSean McCoy, James Jones and Chase Daniel predict who will win the NCAA Tournament between Duke, Houston, Florida and Auburn. This is the first year all No. 1 seeds are in the Final Four since 2008.

That's why it's one of the best sporting events in the world to watch. To an extent, the norm has been broken this season with a historic Final Four field on tap. If you love underdogs, this might be a forgettable weekend for you.

The Final Four is loaded, and basketball nerds are hyperventilating. But only one thing would surprise: Duke not winning it all.

The Michigan State Spartans pulled off a win against No. 6 seed Ole Miss on March 28, and doing so, they earned themselves a spot in the Elite Eight. It was a tight, 73-70 win victory, but a win is a win.

The Blue Devils’ trip to San Antonio, after Saturday’s 85-65 win over Alabama, was the product of years of planning to build around Cooper Flagg, and hard-learned lessons.

Just as they did in the 2024 NCAA Tournament, Duke and Houston will play in March Madness this season. This time it’s in the Final Four national semifinals at San Antonio.