The complement receptors C3aR and C5aR1, whose signaling is selectively activated by anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune responses. Dysregulations ...

Heightened sinonasal complement activation is present in CRSwNP, and local sinonasal complement C3 levels correlate with subjective patient disease severity. Complement anaphylatoxin antagonism ...

Faster and better recovery after stroke may be the result of a newly discovered treatment strategy that created new nerve synapses in the brain—a key factor for learning. A study at Sahlgrenska ...

Dysregulated complement pathways are linked to progression from iAMD to advanced AMD, including NVAMD and GA. Higher systemic levels of C4, C4b, and a reduction in C3 are associated with increased ...

A new study published in the journal Science Immunology analyzed lung epithelial cells from patients infected with COVID-19 and found the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ...