Nature

Structural basis for engagement by complement factor H of C3b on a self surface

The ~30 proteins of the complement system cooperate to make a vital contribution to innate immunity 1. The complement system is important for clearing immune complexes and cellular debris and for ...
BioSpace

Genentech Presents Interim Phase III Data Showing Sefaxersen Significantly Reduced Proteinuria in People With IgA Nephropathy (IgAN)

Sefaxersen achieved a statistically significant 43.1% reduction in proteinuria, a key indicator of kidney damage, relative to ...
Nature

Complement factor H deficiency and endocapillary glomerulonephritis due to paternal isodisomy and a novel factor H mutation

Discover the latest articles and news in related subjects. Here, we describe a patient with an early onset of endocapillary glomerulonephritis and CFH deficiency. Genetic analyses revealed uniparental ...
The New England Journal of Medicine

Factor H Autoantibodies and Membranous Nephropathy

Panel A shows anti-CFH and anti–phospholipase A2 receptor (PLA2R) antibody concentrations in the patient’s serum at different time points. Anti-CFH concentrations increased over time, whereas ...