RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate immune system. This polymerase transcribes viral genomes to produce RNAs that lead to induction of type I ...
All three RNAPs have catalytic cores consisting of 10 subunits. Five of these are core subunits which form crab claw shapes with DNA at their centres, channels for RNA products and NTP substrates as ...
As expected, accuracy also depended on whether the DNA polymerase retains a 'proofreading' functionality, which verifies (and if necessary removes) any mismatched nucleotides: a version of the enzyme ...
The latest short science news items from C&EN. Ting F. Zhu, who led the work, says it is a step on the way to creating a mirror version of the so-called central dogma of molecular biology, which ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 15 (Jul. 17, 2001), pp. 8376-8380 (5 pages) The β and proliferating cell nuclear antigen (PCNA) sliding ...
Researchers show that polymerase theta can efficiently convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells. Editor's Note: Thomas Jefferson University issued the ...
A common hallmark of viral genome replication is a high mutation rate, which can aid in their ability to evade new treatments and acquire resistance to once-effective antiviral medications. Now, a new ...
Forbes contributors publish independent expert analyses and insights. William A. Haseltine, Ph.D., covers genomics and regenerative medicine This is part twenty of a series, “How SARS-CoV-2 Delays, ...
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