A computational study focused on the mechanistic pathway of the SpnF-catalyzed cycloaddition reaction leading to Spinosyn A -- tetracyclic natural insecticide produced by the cells of the bacterium ...

The Diels-Alder reaction is a classic transformation that typically marries a diene (with four π electrons) and an alkene (with two π electrons) to form a six-membered ring—it’s known as a [4+2] ...

The use of 1-hydrazinodienes in the Diels-Alder reaction is adding a new twist to the well-studied reaction: The cycloaddition product may be driven to rearrange, according to research by Princeton ...

Maleic anhydride is perhaps best known as the quintessential dienophile in the Diels–Alder cycloaddition reaction, but it is also used as a ligand in metal complexes and as a feedstock for maleic acid ...

Until recently it was assumed that cycloaddition reactions (also widely known as the Diels-Alder reactions) do not occur in nature, since corresponding enzymes were never discovered. However, it was ...