JSTOR Daily

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Trims MHC Class I-Presented Peptides in vivo and Plays an Important Role in Immunodominance

CD8⁺ T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate ...
JSTOR Daily

Arabidopsis Class I α-Mannosidases MNS4 and MNS5 Are Involved in Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins

Silvia Hüttner, Christiane Veit, Ulrike Vavra, Jennifer Schoberer, Eva Liebminger, Daniel Maresch, Josephine Grass, Friedrich Altmann, Lukas Mach and Richard Strasser To ensure that aberrantly folded ...
Case Western Reserve University

DJ-1 is critical for the integrity and function of endoplasmic reticulum-mitochondria tethering

DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...
Business Wire

Quentis Therapeutics Debuts with $48 Million Series A Financing to Advance First-in-Class Immunotherapies Targeting Endoplasmic Reticulum Stress Response Pathways

NEW YORK--(BUSINESS WIRE)--Quentis Therapeutics Inc., a biotechnology company pursuing next-generation immuno-oncology research and drug development, debuted today with the completion of a $48 million ...