We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR) stress response as a previously unexplored therapeutic vulnerability in MYC-driven breast ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system.

The transcription factor XBP1, which is activated by the ER transmembrane protein IRE1 (inositol-requiring transmembrane kinase/endonuclease 1), is an important component of the UPR. XBP1 induces ...