News Medical on MSN1d
Unfolded protein response: A key regulator of intestinal health and disease
The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and ...
Baylor College of Medicine4y
Project 3: Targeting Endoplasmic Reticulum Stress Sensor IRE1 to Enhance Chemotherapy Sensitivity in MYC-driven Breast Cancer
We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR) stress response as a previously unexplored therapeutic vulnerability in MYC-driven breast ...
Nature5y
Mismanaged ER stress and inflammation
The transcription factor XBP1, which is activated by the ER transmembrane protein IRE1 (inositol-requiring transmembrane kinase/endonuclease 1), is an important component of the UPR. XBP1 induces ...