A schematic diagram illustrates a proposed mechanism of interferon-γ (IFN-γ)-induced downregulation of tricellulin in salivary epithelial cells. IFN-γ leads to the phosphorylation of signal transducer ...

Molecular Biology of Anaplastic Lymphoma Kinase–Positive Anaplastic Large-Cell Lymphoma PURPOSE: The toxicity associated with adjuvant high-dose interferon-alfa-2b therapy (HDI) for high-risk melanoma ...

Researchers have revealed the regulatory mechanism of a specific protein that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help ...

Goto et al. 1 recently described a novel mechanism of immune evasion during the initial steps in the development of colorectal cancer in which nascent cancer cells reactivate a fetal program that is ...

PURPOSE: The toxicity associated with adjuvant high-dose interferon-alfa-2b therapy (HDI) for high-risk melanoma can lead to premature discontinuation. It is important to understand the expected ...