Intracellular peptides, generated predominantly via the ubiquitin–proteasome system, have emerged as critical modulators of cell signalling. These peptides play multifaceted roles, ranging from ...
New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and ...
New study shows that targeting an oft-drugged family of cell membrane receptors with biased modulators can expand potential ...
About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane ...
Background: Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/ß-catenin signaling promotes the development of ...
Long-term and precise intracellular signal detection is critical for advancing our understanding of brain diseases and developing effective diagnostic tools. A breakthrough method has been introduced ...
Expression of a psoriasis-associated gain-of-function human CARD14(E138A) mutant protein in intestinal epithelial cells ...
About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G ...
G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...
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