Central nervous system prophylaxis is recommended with the administration of high-dose methotrexate and/or intrathecal injection of chemotherapy in patients with anaplastic large-cell lymphoma (ALCL).
A novel indwelling subcutaneous intrathecal catheter circumvented the complex spine anatomy of patients with spinal muscular atrophy (SMA), a challenge when giving nusinersen via intrathecal injection ...
Incorporating Precision BH3 Warheads Into the Offensive Against Acute Myeloid Leukemia Alliance/CALGB 50303 (NCT00118209), an intergroup, phase III study, compared dose-adjusted etoposide, prednisone, ...
Intrathecal dosing of the high dose first-generation construct resulted in nearly complete normalization of impaired open field and motor function and more than doubled median life expectancy in ...
Intrathecal drug delivery involves administering analgesic medications directly into the cerebrospinal fluid, thereby achieving targeted pain relief while minimising systemic side effects. This method ...
The objective of this retrospective chart review and database development was to identify trends in ITB management to better choose, educate, and treat patient swith severe spasticity. Findings ...
In vitro cytotoxicity studies were performed in MCF-7, Molt-4, and rhabdomyosarcoma cell lines. Feasibility and pharmacokinetic studies were performed in nonhuman primates. These preclinical studies ...
Use of intrathecal morphine during surgery or labor significantly increases the risk for postoperative nausea and vomiting (PONV), pruritus, and urinary retention, according to a meta-analysis.