The low-to-moderate resolution of linkage analysis in complex traits has underscored the need to identify disease phenotypes with presumed genetic homogeneity. Bipolar disorder (BP) accompanied by ...

We have optimized and parallelized the GENEHUNTER-TWOLOCUS program that allows to perform linkage analysis with two trait loci in the multimarker context. The optimization of the serial program, ...

In a paper published on March 28 in Sciencexpress, Rachel Brem and colleagues describe how linkage analysis and gene expression profiling can be combined to dissect transcriptional regulatory networks ...

In this paper we propose a new class of statistics to test a simple hypothesis against a family of alternatives characterized by a mixture model. Unlike the likelihood ratio statistic, whose large ...

The paper undertakes a linkage analysis on a regional economy, concentrating on tourism-related sectors. Recent improvements in the accounting for tourism activity, through satellite account ...