Opening of the mitochondrial permeability transition pore (MPTP) has been shown to be key to the development of experimental acute pancreatitis. The findings pinpoint MPTP as a potential new drug ...

The fact that MPTP causes parkinsonism in humans is a major incentive for using this toxin to study PD pathogenesis and, at the same time, the reason why safety measures must be so rigorous. The three ...

More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson's disease. In a new study led by scientists from the ...

Until five years ago, scientists investigating Parkinson’s disease were frustrated in their attempts to unravel the biochemical mechanism of this debilitating disease. Lacking an animal model, they ...

The MPTP is a pore generated within the mitochondrial inner membrane, which dissipates the membrane potential needed to generate ATP. If prolonged opening occurs, a cell dependent on mitochondrial ATP ...

In 1982, a tainted drug caused a handful of young Californians to become mysteriously frozen, unable to move. Their doctor’s ensuing investigation helped catalyze the start of modern Parkinson’s ...

NRG Therapeutics Ltd. has been awarded a grant from Target ALS Foundation to support its discovery program for a treatment for amyotrophic lateral sclerosis (ALS).

A research team led by scientists at Cincinnati Children’s Hospital has uncovered a new potential approach to preventing the muscle-wasting symptoms of muscular dystrophy (MD), a family of genetic ...