Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Located at the cellular interface, membrane proteins play critical regulatory roles in the signaling between a cell and its interacting environment, making them popular and ideal drug targets.

Drug discovery requires two separate steps: checking whether a drug can bind to a harmful molecule or its receptor, and ...

There’s no doubt that large language models and generative AI tools have taken the world by storm. Their ability to create, ...

A drug candidate (pink) found to bind to the pocket between the cancer-related protein CCNE1 (green) and its partner CDK2 (blue) using the new paralog-hopping approach. LA JOLLA, CA—Some proteins in ...

Viruses attack nearly every living organism on Earth. To do so, they rely on highly specialized proteins that recognize and ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Designing drugs is a bit like playing with Polly Pocket. The vintage toy is a plastic clam shell that contains a multi-bedroom house, a skating rink, a disco dance floor, and other fun scenarios. Kids ...

An international research team has succeeded in deciphering a key mechanism that controls the growth of pancreatic cancers.

The company joins a group of degrader ADC (or DAC) developers that includes Bristol Myers Squibb and Pfizer.