Drug discovery requires two separate steps: checking whether a drug can bind to a harmful molecule or its receptor, and ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

The SARS-CoV-2 virus is continuously evolving and structural changes to the virus may impact the efficacy of antibody therapies and vaccines. A study describes the structural and functional landscape ...

One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells. From beta blockers to antihistamines, these essential, life-saving medications ...

Up to 20% of hormone receptor-positive breast cancers don't respond to antiestrogen therapies. A study led by researchers at ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

BUFFALO, N.Y. – Touch a hot plate and your hand flies back. While the response is almost instant, researchers are still working to better understand the molecular mechanisms behind these sensations of ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Researchers found that individuals have distinct baseline levels of brain-derived proteins in cerebrospinal fluid, masking ...