Pyruvate is produced by glycolysis, a process in which carbohydrates are broken down to create energy. Calcium pyruvate is a popular supplement that many people use primarily for its purported weight ...

Endogenous pyruvate is an end-product in glycolysis and a key molecule for ATP production under aerobic and anaerobic conditions, whereas exogenous pyruvate is transferred to cells via monocarboxylate ...

Cancer metastasis is a crucial area in cancer research that directly affects patient survival and treatment outcomes. Cancer cells often undergo adaptive metabolic changes during metastasis from in ...

Image Caption: Pyruvate inhibits TNFα/NF-κB signaling and the expression of downstream pro-inflammatory genes. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles ...

An article in Protein & Cell discusses the multifactorial nature of obesity, highlighting its association with chronic low-grade inflammation, or meta-inflammation, which contributes to metabolic ...

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

The present study was instituted to determine whether children with congenital heart disease have abnormal blood levels of lactate and pyruvate and to determine whether a relation exists between ...

Ulcerative colitis (UC) is a chronic inflammatory disease marked by intestinal pain, bleeding, and impaired gut barrier function. At the heart of the disease lies TNFα-induced NF-κB signaling, which ...