The molecular architecture of a protein complex that helps determine the fate of human cells has been imaged for the first time by researchers with the U.S. Department of Energy’s Lawrence Berkeley ...

Genetic, biochemical and structural studies have implicated Argonaute proteins as the catalytic core of the RNAi effector complex, RISC. Here we show that recombinant, human Argonaute2 can combine ...

Recent studies are revealing more about how the protein complex called RISC--RNA-induced silencing complex--works. RISC is at the heart of the gene-silencing technique called RNA interference, which ...

Human Argonaute 1 protein (cyan) bound to let-7 microRNA (magenta). Ago protein family plays a role in RNA silencing processes. Cartoon model with semi-transparent surface. Shutterstock | petarg ...

RNA interference (RNAi) is a eukaryotic gene-regulatory pathway that silences the expression of specific genes in response to homologous double-stranded (ds)RNA. The RNA-induced silencing complex ...

Electron microscopy structure of the human RISC-loading complex, with the L-shaped Dicer enzyme shown as a wire map and the Argonaute2 protein, shown in purple. Disclaimer: AAAS and EurekAlert! are ...