“Our study enables us to envisage a global picture of genes and pathways dysregulated during senescence and provides novel evidence for involvement of p53/p16/RB-E2F-DREAM repressional targets in this ...

There exists a complex synergistic relationship among cancer, circadian rhythms, and aging: aging is a major risk factor for cancer, disruption of circadian rhythms promotes tumor initiation and ...

T cell senescence occurs in the TME, affecting cancer prognosis and immunotherapy efficacy. The TME induces T cell senescence through multiple pathways, including persistent stimulation by ...

Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular ...

Share on Facebook. Opens in a new tab or window Share on Bluesky. Opens in a new tab or window Share on X. Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window Senescence ...

After a finite number of divisions, cells simply give up. As each round of replication trims their telomeres—the protective caps at the chromosome ends—those caps eventually become too short to ...

These patients can get as many as five different cancers before the age of 70, indicating that in people with normal length telomeres, the telomere tumor suppressor pathway prevents many cancers." ...

As the age of the general population increases, so does the need for precision treatments for age-related cardiac health decline. Heart failure is a rising global cardiovascular epidemic driven by ...

Low-grade inflammation contributes to age-related decline and impairment, but the precise pathways responsible for this inflammation and their impact on natural aging have until now remained elusive.

Could a 70-year-old high blood pressure medicine hold the secret to stopping one of the deadliest brain cancers? New research indicates that hydralazine, a vasodilator introduced in the 1950s, ...