Thyrotropin-releasing hormone (TRH) is a small yet highly significant tripeptide consisting of the amino acids pyroglutamate, histidine, and proline. First identified in the hypothalamus, TRH was ...

We tested him with an injection of TRH and his TSH levels increased, indicating that his pituitary was capable of making TSH. His pituitary did not release TSH because the hypothalamic signal was ...

Although TRH and TSH administration are theoretically ideal for treatment of CH, they have been abandoned because of high monetary costs, limited applicability and instability of TRH after oral ...

We report on a family with recessive resistance to the action of thyrotropin-releasing hormone (TRH) due to a nonsense homozygous mutation in the TRH receptor (TRHR) gene (p.R17X). We examined the in ...

Regulation of thyroid hormone (TH) levels is a complex multilevel phenomenon. The paraventricular nucleus (PVN) of the hypothalamus (the region of the brain that controls the involuntary nervous ...

The thyroid, a butterfly-shaped gland at the base of the neck, regulates metabolism, energy levels, digestion, and reproductive health. Thyroid disorders are among the most common endocrine conditions ...

Herein, the authors show, using wild-type and the Pax8 ablated model of hypothyroidism in mice, that hyperthyroidism and severe hypothyroidism are associated with an overall unhealthy status and ...

Levels of thyroid hormones in serum are tightly regulated by the hypothalamic-pituitary-thyroid axis (Figure 1). Hypothalamic TSH-releasing hormone (TRH) is secreted mainly from the paraventricular ...