The top-seeded Cougars were in enemy territory at Midwest Region games in Indianapolis, but they dominated Tennessee in Sunday’s region final to reach the Final Four.

It’s the Duke Blue Devils vs Houston in the Final Four of the March Madness bracket. Here’s our prediction, pick for the 2025 NCAA Tournament game.

The college basketball season has hit its climax, as the Final Four in San Antonio is set to begin Saturday with the national semifinals. The tournament hasn't been particularly notable so far, but all four semifinalists are No. 1 seeds ( Houston, Duke, Florida and Auburn ), the first time that's happened since 2008.