Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog signalling pathway. A new study from the Karolinska Institutet, published in ...

Siglec-15 has traditionally been understood as an immune checkpoint molecule, primarily located on the cell membrane where it suppresses T-cell function. However, the new research revealed that in SHH ...

A discovery with major implications for cancer treatment has been made by a team of researchers from Rensselaer Polytechnic Institute (RPI), the University of Nebraska Medical Center (UNMC), ...

Chengdu Sibeibo Pharmaceutical Technology Co. Ltd. has divulged deuterated derivatives of taladegib acting as Hedgehog signaling inhibitors and protein smoothened (SMO) antagonists reported to be ...

Please provide your email address to receive an email when new articles are posted on . Adverse events reported with ENV-101 have been seen with other hedgehog inhibitors. Another trial is already ...

Researchers at University of California San Diego School of Medicine and Mayo Clinic provide the first evidence that the Hedgehog signaling pathway is central to the formation of gastrointestinal ...