The midbrain contains three populations of dopaminergic neurons. One group, in the substantia nigra (SN), projects to the dorsal striatum. These neurons are important for the control of movement and ...
The dopamine hypothesis of schizophrenia posits that increased subcortical dopamine underpins psychosis. In vivo imaging studies indicate an increased presynaptic dopamine synthesis capacity in ...
The death of dopaminergic neurons in the substantia nigra is the defining feature of Parkinson’s disease, but not all neurons in the region suffer this fate. Why do some wither while others survive ...
The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A deficiency of this substance can have drastic consequences: The death of dopamine-producing nerve cells in the ...
Parkinson's disease is characterized by the progressive loss of dopamine neurons in the substantia nigra of the midbrain. These neurons project widely throughout the cerebral hemispheres, but the ...
There are three dopaminergic pathways, namely the striatonigral pathway (substantia nigra to caudate and putamen), the mesolimbic pathway (ventral tegmental area of midbrain to limbic areas of basal ...
At the AD/PD meeting held last month in Vienna, scientists implicated T lymphocytes—specifically, the cytotoxic, CD8-positive variety—in Alzheimer’s disease. While the modus operandi of these cells in ...
New findings published in the journal Nature Neuroscience have shed light on a mysterious pathway between the reward center of the brain that is key to how we form habits, known as the basal ganglia, ...
Parkinson’s disease (PD) is a neurodegenerative disorder marked by the selective loss of midbrain dopamine (mDA) neurons in the substantia nigra. Human pluripotent stem cells (hPSCs) offer a promising ...
Deep in the human brain, a very specific kind of cell dies during Parkinson’s disease. For the first time, researchers have sorted large numbers of human brain cells in the substantia nigra into 10 ...
The cerebellum ("little brain") is tucked underneath the basal ganglia; it sits in the back of the skull below the cerebrum. Source: CLIPAREA l Custom media/Shutterstock Neuroscientists have unearthed ...
The neurotransmitter dopamine influences the activity of a wide variety of brain areas. A deficiency of this substance can have drastic consequences: The death of dopamine-producing nerve cells in the ...
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