Ribosomes are the sites in a cell in which protein synthesis takes place. Cells have many ribosomes, and the exact number depends on how active a particular cell is in synthesizing proteins.

Northwestern Medicine scientists have uncovered new details explaining how poxviruses manipulate host cells to enhance their ...

At this point, translation must be terminated, and the nascent protein must be released from the mRNA and ribosome. Termination of Translation There are three termination codons that are employed ...

We showed that non-AUG translation is strikingly resistant to multiple protein synthesis inhibitors, including cycloheximide. We find that these inhibitors slow elongating ribosomes, thereby inducing ...

This research thoroughly elucidates the dynamic multi-conformational characteristics of ribosomes during the translation process. "Understanding the entire translation process in depth helps us ...

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site ...

The catalytic center of the ribosome, known as the peptidyl transferase center (PTC), is composed entirely of rRNA. The PTC is highly conserved across all domains of life, highlighting the fundamental ...

Ramakrishnan, a distinguished structural biologist and Nobel Laureate in Chemistry (2009), is renowned for his groundbreaking ...

playing a key role in two translation stages: initiation and elongation (helping ribosomes move along the mRNA and add amino acids to the protein chain). Specifically, eIF-5A helps when the ...

In this valuable study, Roiuk et al employed a combination of ribosome profiling and reporter assays to provide convincing evidence that eIF2A is not involved in translational regulation in cultured ...