Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3-point favorites, according to the latest ...

Needing depth on the defense, San Francisco waived quarterback Adrian Martinez and added Clelin Ferrell to the 53-man roster ...

USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers ...

Charlotte native Owen McCown led the Roadrunners' offense with 306 yards, three total touchdowns, and an interception in his ...

The San Francisco 49ers have to give a lot of love to Mac Jones, who truly stepped up for them in a massive way. The 49ers ...

The Arizona Cardinals have a lengthy injury report ahead of Week 11, with seven players officially ruled out against the San ...

Quarterback Brock Purdy returns to the starting lineup for the San Francisco 49ers this week after missing six games with a ...

The San Francisco 49ers and Arizona Cardinals will meet on Sunday at State Farm Stadium. Here's who experts think will win ...

The Los Angeles Rams were in Santa Clara today for their second meeting with the San Francisco 49ers, a rematch of their Week ...

The NFC West is loaded at the top, and two of the division's contenders meet on Sunday when the 6-3 San Francisco 49ers host ...

Thomas Valentine of Pro Football Focus spotlighted Kittle against Budda Baker as his matchup to watch in the game. While that ...

The San Francisco 49ers are looking to find their footing as they take on the Arizona Cardinals on Sunday afternoon. The 49ers have alternated wins and losses s ...