Abstract: Co-optimizing mRNA sequences for both codon optimality and secondary structure is crucial for producing stable and efficacious mRNA therapeutics. Codon optimization, which adjusts nucleotide ...

Jacory Croskey-Merritt of the Washington Commanders runs the ball against the Los Angeles Chargers at SoFi Stadium. Luke Hales / Getty Images Every week, there’s a new tale. The Jaguars embarrass the ...

The Reverse Translate tool is a professional bioinformatics application designed to back-translate protein sequences into optimized nucleotide sequences. While the natural biological flow (Central ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of ...

Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University ...

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FORGET THE elephant shrew—meet the mammoth mouse. On March 4th Colossal Biosciences, a company trying to revive long-gone species, announced that they had genetically engineered a Mus musculus to have ...

This study develops a useful metric for quantifying codon usage adaptation - the Codon Adaptation Index of Species (CAIS). This metric permits direct comparisons of the strength of selection at the ...

To expand the periodic table, it might be time to go titanium. A new study lays the groundwork to expand the periodic table with a search for element 120, to be made by slamming electrically charged ...