Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible ...

Researchers have created the most comprehensive map to date of DNA elements that regulate gene activity, nearly tripling the ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most ...

Spina bifida and anencephaly are neural tube defects caused by failure of embryonic neural tube closure. Successful closure requires apicobasal elongation and apical constriction of neuroepithelial ...

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A ...

Universal rRNA depletion can put the power of RNA-seq at the disposal of researchers studying any organism, from dangerous pathogens to vital plant crops. The RNA sequencing (RNA-seq) revolution is ...

According to research from a team at the University of Utah Health and the University of Nevada, Reno School of Medicine, ...