The DENND1B gene is also found in humans, in whom it was also associated with higher body mass, the researchers found. Before this study of labrador genetics “no one suspected that [DENND1B] gene had ...

That was true of our top Labrador obesity gene, DENND1B. Dogs who carried the problem version of this gene had around 8 per cent more body fat, but the effect in humans is only subtle.

While all dogs have a gene called DENND1B, the researchers discovered that those with a particular variant of DENND1B—called rs24430444—had approximately 8% more body fat than those without it.

Genetic variants associated with canine obesity, particularly DENND1B, are also associated with obesity in humans, new research revealed. Notably, labrador retrievers carrying DENND1B had around 7 ...

For Raffan, the study has two major takeaways: first, it sheds new light on how DENND1B affects a brain pathway responsible for regulating energy balance and appetite.

The DENND1B gene influences hunger signals in the brain, making those with the variant more prone to overeating. Researchers say the findings shed light on how genetic risk contributes to obesity ...

The DENND1B gene, previously linked to obesity in people, was found to alter hunger signals in Labradors, making them more prone to overeating. Researchers at the University of Cambridge analyzed the ...