The pharmaceutical company is running investigational new drug experiments, studies required by the FDA to demonstrate the ...

Ubiquitination is a crucial post-translational modification process where the small protein ubiquitin is attached to target proteins, marking them for degradation or altering their function. This ...

The FDA's orphan drug designation supports LP-284's development for soft tissue sarcomas, addressing significant unmet needs in this adult patient population. The FDA granted orphan drug designation ...

Scientists are searching for therapeutics that mimic the life-extending benefits of caloric restriction, exercise, and a good ...

In a new study, scientists at the Max Planck Institute for Evolutionary Anthropology in Leipzig analyzed the impact of more than 2,000 clinically approved drugs on DNA repair and CRISPR genome editing ...

In the interests of transparency, eLife publishes the most substantive revision requests and the accompanying author responses. [Editors' note: this paper was reviewed by Review Commons.] Thank you ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

I've been lurking and dipping in and out of this thread, and have a scattered assortment of thoughts and somewhat-relevant expertise that I've finally decided to express in words. My bona fides: I've ...

1 Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Immunotherapy, Chongqing, China 2 Department of Pathology, The Second ...