Northwestern Medicine scientists have uncovered new details explaining how poxviruses manipulate host cells to enhance their ...

Ramakrishnan, a distinguished structural biologist and Nobel Laureate in Chemistry (2009), is renowned for his groundbreaking ...

Recent research has focused on understanding the structural and functional diversity of IRESs, their interaction with ribosomes, and the implications for viral translation and infection.

Translation initiation: The process by which ribosomes begin synthesizing proteins from messenger RNA (mRNA). This Nature Research Intelligence Topic summary is one of 30,000 created with ...

Ribosomal translation is the process by which cells synthesize proteins based on the genetic instructions encoded in messenger RNA. It is essential for life, yet it is an incredibly complex process ...

We showed that non-AUG translation is strikingly resistant to multiple protein synthesis inhibitors, including cycloheximide. We find that these inhibitors slow elongating ribosomes, thereby inducing ...

Scientists have unveiled insights into how HIV-1, the virus responsible for AIDS, skillfully hijacks cellular machinery for its own survival. By dissecting the molecular interplay between the virus ...

In this valuable study, Roiuk et al employed a combination of ribosome profiling and reporter assays to provide convincing evidence that eIF2A is not involved in translational regulation in cultured ...

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site ...

Proteins, the pillars of cellular function, often assemble into “complexes” to fulfill their functions. A study by the ...