Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

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N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

This cover highlights the article Early coordination of cell migration and cardiac fate determination during mammalian gastrulation by Shayma Abukar, Kenzo Ivanovitch and colleagues. Using long-term ...

Antibiotic resistance frequently results in delayed adequate antibiotic treatment, increasing morbidity and mortality. AMR is the inherited ability of microorganisms to grow at high antibiotic ...

While only 1–2% of the human genome encodes proteins, the remaining repetitive, low-complexity part is poorly characterized, and was long referred to as “junk DNA” (ENCODE Project Consortium 2012; ...

The mitochondrial proteome is a genetic mosaic of nuclear and mitochondrially encoded proteins (Morgenstern et al, 2017; Rath et al, 2021).The mitochondrial genome is tiny and encodes only for a small ...

Exhaustion of CD8 + T-cells leads to their reduced immune functionality and is controlled by numerous transcription factors. Here we show that the transcription factor IRF-5 helps to limit functional ...

DDR and metabolism are bidirectionally linked (Cucchi et al, 2021; Turgeon et al, 2018).We and others have shown that ATR and ATM have roles in metabolism (Aird et al, 2015; Chen et al, 2020; Dahl and ...

Among the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of effectors modify host proteins by ...

Brain metastasis (BM) remains a significant challenge in breast cancer (BC) management. While conventional metastatic routes primarily involve hematogenous dissemination, emerging evidence suggests ...