Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs).

NMD regulates numerous biological functions in a diverse range of cells, such as contributing to the synaptic plasticity of neurons which shapes adult behavior.

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The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular …

4 days ago · NMD Pharma presented new Phase 2a SYNAPSE-CMT trial data evaluating ignaseclant in adults with CMT1 and CMT2 at the 2026 MDA Clinical & Scientific Conference.

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Dec 1, 2024 · It is crucial to comprehend the long-term effects and potential risks associated with therapeutic modulation of NMD. In this review, we briefly discuss NMD’s mechanism of action and …

4 days ago · NMD Pharma late-breaking oral presentation at MDA with top-line safety and efficacy data from the SYNAPSE-CMT Phase 2a study of ignaseclant in Charcot-Marie-Tooth disease types 1 and 2.