A senolytic (from the words senescence and -lytic, "decomposition or breakdown") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent …

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven approach.

In this review, we present the senolytic drugs as a promising way to treat age-related diseases but also their limitations during clinical development.

Feb 1, 2024 · Senolytic effect is heterogeneous depending on cell type and senescence trigger. Combinatorial senolytics have been pursued to address senescence heterogeneity. Calcium …

Jul 21, 2025 · Senolytics are a class of compounds being investigated for their potential to address aspects of aging. These molecules are designed to selectively target and clear specific cells from the …

Feb 7, 2023 · For this purpose, researchers have recently developed a new class of pharmaceutical agents called senolytics. The majority of senolytics are derived from a class of molecules called …

Oct 27, 2023 · Unlike classical chemotherapy, which relies on the rapid division of cancer cells for efficacy, senolytic drugs target non-dividing senescent cells. These drugs interfere with the anti …

Mar 9, 2025 · This review provides a comprehensive overview of the current senolytic landscape, encompassing various classes of senolytic drugs, their mechanisms of action, and the evolving …

Jun 4, 2025 · Senolytic drugs represent a new frontier in therapeutics, specifically designed to selectively eliminate senescent cells. These cells, which accumulate with age, significantly contribute …

Apr 30, 2025 · Recent advances in senotherapeutics have led to two principal strategies for targeting senescent cells: senolytics, which selectively induce their apoptosis, and senomorphics, which …